Synthetic Route of 1835-65-0, A common heterocyclic compound, 1835-65-0, name is 3,4,5,6-Tetrafluorophthalonitrile, molecular formula is C8F4N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
COMPARATIVE EXAMPLE 2Preparation of a Vanadyl Phthalocyanine CompoundlOg of 3,4,5,6-tetrafluorophthalonitrile, lOg ofthiophenol and 7 g of potassium fluoride were added to 3 neck flask equipped with a reflux apparatus, and then 30 ml of acetonitrile was added as a solvent, and the mixture was reacted withstirring for 12 hours at room temperature. Afier reaction was completed, 7 g of 2,6-dimethylphenol and 4 g of potassium fluoride were added to the reacting solution, and then refluxed for 8 hours. Afier reaction was completed, the solution was distilled with a vacuum distillet 20 g of crude reactantsobtained as above were added to 3 neck flask equipped with a reflux apparatus, and refluxed with 2 g of vanadium trichloride, 2 g of 1-octanol and 30 g of benzonitrile for 8 hours. Afier reaction was completed, the solution was distilled with a vacuum distiller to obtain a vanadyl (vanadium oxide) phthalocyaniene (VOPc: Oxo-Vanadium Phthalocyanine)30 based precursor compound VOPc(PhS)8{2,6-(CH3)2PhO}4F4. 10 g of the vanadyl phthalocyanine-based precursor compound and 50 ml of cyclohexylamine were added to 3 neck flask equipped with a reflux apparatus, and reacted for 8 hours at 60¡ã C. Afier reaction was completed, the reactingsolution was concentrated in vacuum to obtain a vanadyl phthalocyanine compound VOPc(PhS)8{2,6-(CH3)2PhO}4 (C5H11NH)4 (Ph=phenyl; in the formula 2 below, A2, A3, A5, A7, A10, A11, A14 and A15 are PhS; A1, A5, A9 and A13 are {2,6-(CH3)2PhO}; and A4, A8, A12 and A15 are C5H11NH)represented by the formula 2
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SK CHEMICALS CO., LTD.; Kang, Ju-Sik; Park, Jeong-Ho; Chang, Yu-Mi; US9158048; (2015); B2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts