Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33279-01-5, name is 3-Oxopentanenitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Oxopentanenitrile
Step: 1H- thieno[3,2-c] pyrazole-5-carbaldehyde (200mg, 1.314mmol) (see preparation step togetherPreparation Example 1 a) and 3-oxopentanenitrile (191mg, 1.972mmol) wasdissolved in dichloromethane together (20 mL), add The piperidine (11mg,0.131mmol), glacial acetic acid (12mg, 0.197mmol), under nitrogen at refluxovernight trans should. The filtered reaction mixture was cooled to roomtemperature, was added absolute ethanol (20 mL) was diluted reaction mixturewas stirred for ten minutes, filtered It was concentrated to dryness and theresidue was added ethyl acetate (5mL) and petroleum ether (10 mL), stirred forfive minutes and filtered, the solid Dried to give 2 – ((1H- thieno [3,2-c]pyrazol-5-yl) methyl-enyl) -3-oxo-valeronitrile (190mg, 62.5%). ESI-MS: 232 [M+ H].
The synthetic route of 33279-01-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Huilun life Science & Techonology Co.,Ltd; Cheng, Jianjun; Qin, Jihong; Ye, Bin; (68 pag.)CN103467481; (2016); B;,
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