Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 691877-03-9, name is 3-Bromo-5-(trifluoromethyl)benzonitrile, This compound has unique chemical properties. The synthetic route is as follows., Safety of 3-Bromo-5-(trifluoromethyl)benzonitrile
43-2 (50 mg, 0.200 mmol) was dissolved in THE (1 mL) before 1M Borane in THF (1 ML) was added. The mixture was stirred at RT overnight before concentrated IN VACUO. The residue was redissolved in a solution of 1% HCl (4N in dioxane) in methanol and heated at 50 C overnight. Solvent was stripped off and redissolved in 1% HCl in methanol. This process was repeated three times to get ride of excess borane and yield crude 43-3 (50 mg, 98.4%). LC-MS: MW calculated 252.97, found 253.8.
According to the analysis of related databases, 691877-03-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK & CO., INC.; WO2004/41279; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts