In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120351-94-2 as follows. name: 3-(2-Aminoethoxy)benzonitrile
Step 1: To a solution of 3-(2-aminoethoxy)benzonitrile (276 mg, 1 mmol, 1.0 equiv) in 5 mL of methanol at room temperature was added TEA (630 muL, 4.5 equiv) and 4-bromophthalic anhydride (227 mg, 1.0 equiv). After stirring at room temperature for 3 h, the solvent was evaporated and the residue was vacuum dried. The residue in 10 mL of pyridine was then treated with 12 mL of acetic anhydride at room temperature overnight. The volatile solvent was evaporated, and the residue was taken up with EtOAc, washed with H2O, dried over MgSO4 and column purified with 1:3 EtOAc/hexanes on silica gel to give 3-[2-(5-bromo-1,3-dioxoisoindolin-2-yl)ethoxy]benzonitrile in 84% yield. LRMS found for C17H12BrN2O3 (M+H)+: 371.05.
According to the analysis of related databases, 120351-94-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2003/114448; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts