68119-31-3, name is 2-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 68119-31-3
(2,2-Difluoro-1,3-benzodioxol-5-yl)-acetonitrile (1.0 eq.), 50 wt% aqueous KOH (5.0 eq.), 1-bromo-2-chloro A mixture of ethane (1.5 eq.) and Oct 4 NBr (0.02 eq.) was heated at 70 C for 1 h. The reaction mixture was cooled and then treated with MTBE and water. The organic phase was washed with water and brine. The solvent was removed to provide (2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarbonitrile.
The synthetic route of 68119-31-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; VERWIJS, MARINUS JACOBUS; ALARGOVA, ROSSITZA GUEORGUIEVA; KAUSHIK, RITU ROHIT; KADIYALA, IRINA NIKOLAEVNA; YOUNG, CHRISTOPHER; (118 pag.)TWI636051; (2018); B;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts