Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5922-60-1, name is 2-Amino-5-chlorobenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H5ClN2
2-Amino-5-chlorophenyl)r4-fluorophenyl)methanone (5-1)To a O0C solution of 1.0M 4-fluorophenylmagnesium bromide in THF (196.6 mL, 196.6 mmol) was added a THF solution (100 mL) of 2-amino-5-chlorobenzonitrile (10.0 gm, 65.5 mmol) over 0.5h. The ice bath was removed and the reaction stirred at ambient temperature for 17 h. The brown solution was cooled in an ice bath, treated with a drop wise addition of aqueous IN HCl (300 mL) and extracted with ether (2x 250 mL). The combined organic extracts were washed with aqueous IN HCl (100 mL), water (2x 150 ml), saturated aqueous sodium bicarbonate (150 ml), brine (100 mL), dried over MgSO4, filtered, concentrated in vacuo to 30 mL and diluted with 60 mL hexane. The resulting precipitate was filtered to give (2-amino-5-chlorophenyl)(4-fluorophenyl)methanone as a yellow solid. IH NMR (CDCl3, 400 MHz) 7.67 (m, 2H); 7.37 (d, J= 2.38 Hz, IH); 7.25 (m, IH); 7.16 (m, 2H); 6.70 (d, J= 8.79 Hz, IH); 5.99 (s). MS (Electrospray): m/z 250.1 (M+H)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5922-60-1.
Reference:
Patent; MERCK & CO., INC.; WO2006/98969; (2006); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts