Some common heterocyclic compound, 55877-79-7, name is 5-Chloro-2-methoxybenzonitrile, molecular formula is C8H6ClNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 55877-79-7
To a glass lined reactor were charged potassium tert-butoxide (1.5 kg/kg, 2.4 equiv) and THF (12.2 kg/kg) at 0 C. A mixture of Compound 4 (1.0 kg), L-methyl-N- formyl hydrazine (1.0 kg/kg, 2.30 equiv) and THF (5.3 kg/kg, 6.0 L/kg) was added slowly. The reactor line was r sed with THF (0.5 kg/kg). The reaction crude was aged at 0 C until reaction reached completion. Water (5.0 kg/kg) was added, and the resulting mixture was aged at 0 C for 30 min, heated to 40 C and aged for additional 30 min. The layers were separated and the aqueous layer was discarded. The organic layer was washed with brine (15 wt%, 5.7 kg/kg) before distilling under vacuum until total volume became approximately 5 L/kg. Four put/take distillations with ethyl acetate (4 x 10 L/kg) were undertaken for the purpose of azeotropic drying. The crude was cooled to 20 C. Sulfuric acid (0.66 kg/kg, 1.10 equiv.) was added, and the slurry was agitated for 2-3 h. Product was isolated by filtration. The cake was consecutively washed with ethyl acetate (2 c 6.5 L/kg) and heptane (8 L/kg), and dried under vacuum at 45 C. Compound 5 was isolated in 99 AP and 83% yield.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 55877-79-7, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ROBERTS, Daniel Richard; (0 pag.)WO2019/232138; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts