Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57381-51-8, name is 4-Chloro-2-fluorobenzonitrile, A new synthetic method of this compound is introduced below., Computed Properties of C7H3ClFN
4-Chloro-2-fluoro-benzonitrile (8.0 g, 50.4 mmol), NaHS^FbO (50.4 mmol, 4.006 g) and DMF (30 mL) were stirred on an ice bath for 1 h. The mixture was partitioned between diethyl ether and HC1 (0.5 M), the organic phase was then extracted with NaOH (2 M, 50 ml) and the aqueous phase was concentrated a little, then acidified with HC1 which gave a precipitate that was isolated and dried to afford the title compound (5.1 g, 59 %). ‘H NMR (400 MHz, Chloroform-^) d 7.53 (d, j= 8.4 Hz, 1H), 7.43 (d, j= 1.7 Hz, 1H), 7.22 (dd, j= 8.4, 1.8 Hz, 1H), 4.15 (s, 1H).
The synthetic route of 57381-51-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GALECTO BIOTECH AB; ZETTERBERG, Fredrik; (118 pag.)WO2019/137971; (2019); A1;,
Nitrile – Wikipedia,
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