Electric Literature of 42872-74-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42872-74-2, name is 3-Bromo-4-methylbenzonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a stirred solution of 3-bromo-4-methyl-benzonitrile (2 g, 10.2014 mmol, 100 mass%) in carbon tetrachloride (20 ml_, 100 mass%) under argon, was added NBS (2.2 g., 12.2417 mmol, 99 mass%) and benzoyl peroxide (0.123 g., 0.5101 mmol, 100 mass%). The mixture was heated to 85C for 18h. The reaction mass was diluted with water (50 ml) and extracted with ethyl acetate. Organics were washed again with water and brine, dried and evaporated to afford 3-bromo-4-(bromomethyl) benzonitrile (1.2 g, 4.4 mmol, 90 mass%, 95% Yield) as an off white solid solid. H NMR (400 MHz, chloroform-c) delta ppm 3.89 – 4.01 (m, 2 H) 6.61 – 6.77 (m, 1 H) 6.92 – 7.07 (m, 2 H) LCMS: RT 1.12-1.49 Min 274 [M+H] +
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-4-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; RAJAN, Ramya; STIERLI, Daniel; BEAUDEGNIES, Renaud; RENOLD, Peter; (79 pag.)WO2016/113303; (2016); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts