Adding a certain compound to certain chemical reactions, such as: 14533-86-9, name is Methyl (E)-2-Cyano-3-phenylacrylate, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14533-86-9, name: Methyl (E)-2-Cyano-3-phenylacrylate
(E)-methyl-2-cyano-3-phenylacrylate 30a (1.40 g, 7.48mmol, 1.0 equiv) and zinc powder (7.83 g, 119.7 mmol,16.0 equiv) were dissolved in 50 mL glacial acetic acid and the solution was stirred for 2.5 h at 100 C. The reaction mixture was filtered through a celite pad and washed with 100 mL EtOAc. The filtrate was neutralised with aq. NaHCO3 solution and the organic layer was separated,washed with brine (2 ¡Á 25 mL), dried over Na2SO4 and the solvent removed under reduced pressure. The crude product was further purified on a silica column with a solvent mixture of 1:9 (EtOAc/hexane) with the desired nitrile isolated as a colourless oil. 6 Isolated yield: 0.583 g (41%, 7.48 mmol),
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl (E)-2-Cyano-3-phenylacrylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mallia, Carl J.; Englert, Lukas; Walter, Gary C.; Baxendale, Ian R.; Beilstein Journal of Organic Chemistry; vol. 11; (2015); p. 875 – 883;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts