These common heterocyclic compound, 368-77-4, name is 3-(Trifluoromethyl)benzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H4F3N
General procedure: Sodium azide, 11.4 mmol, and dimethylamine hydrochloride, 11.2 mmol, were dissolved in 10 mL of DMF, 10 mmol of the corresponding nitrile and 5 mL of DMF were added, and the resulting suspension was heated for 8 h at 110-115C. The mixture was cooled and filtered from the precipitate of sodium chloride, and the precipitate was washed with 10 mL of DMF on a filter. The filtrate was diluted with 30 mL of cold water and acidified with 10% aqueous HCl to pH 2-3. The precipitate was filtered off, thoroughly washed with cold water (3*30 mL), and dried in air. The physical constants and spectral parameters of 3a-3j were in agreement with published data [13, 14].
The synthetic route of 3-(Trifluoromethyl)benzonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Article; Seliverstova; Suslonov; Zarubaev; Trifonov; Russian Journal of Organic Chemistry; vol. 54; 4; (2018); p. 633 – 638; Zh. Org. Khim.; vol. 54; 4; (2018); p. 630 – 635,6;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts