In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 92616-49-4 as follows. Recommanded Product: 4-Bromo-1-naphthonitrile
To a solution of 4-bromo-1-naphthonitrile 10 (5g, 21.7mmol) in 1,4-dioxane and water (V:V=5:1, 100ml), was added bis(pinacolato)diboron (11g, 43.4mmol), PdCl2(dppf) (1.588g, 2.17mmol), KOAc (3.189g ,32.5mmol). The mixture was heated to 90 C and stirred for 16 h under N2. The solution was allowed to cool to room temperature and the water (200ml) was added to the solution. Then the solution was extracted with ethyl acetate (80ml¡Á3). The organic phase was combined and dried over Na2SO4, filtered, and concentrated to give crude 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-naphthonitrile 11 (4.3g, yield = 71%), which was used without further purification.
According to the analysis of related databases, 92616-49-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Yang, Xintuo; Pang, Xuehai; Fan, Lei; Li, Xinghai; Chen, Yuanwei; Bioorganic and Medicinal Chemistry Letters; vol. 27; 9; (2017); p. 1919 – 1922;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts