Electric Literature of 216976-30-6, The chemical industry reduces the impact on the environment during synthesis 216976-30-6, name is 3-Fluoro-5-methylbenzonitrile, I believe this compound will play a more active role in future production and life.
Step 1: 3-(Bromomethyl)-5-fluorobenzonitrile3-Fluoro-5-methylbenzonitrile (Hognda Trading; 100 g, 0.74 mol) was taken in acetonitrile (1 L) at 25C under nitrogen atmosphere. N-Bromosuccinimide (105 g, 0.59 mol) and AIBN (2.4 g, 0.014 mol) were added and the reaction mixture was heated at 70C for 1 h 20 minutes. The reaction mixture was cooled to 25C and concentrated. The residue was diluted, cooled to 0- 5C and stirred for 15 minutes at the same temperature. The precipitated succinimide was filtered and the filtrate was concentrated to get crude product as yellow oil (90 g). It was taken in petroleum ether (200 mL) and cooled to -20C stirred for 30 minutes. The precipitated solids were filtered and dried to get the title product as white solid. 1H NMR (DMSO-d6; 400 MHz): delta 7.83 (m, 2H), 7.73 (m, 1 H), 4.72 (s, 2H). HPLC (Method A) Rt: 4.17 min (Purity: 99.4%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-5-methylbenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SERONO S.A.; BOMBRUN, Agnes; QUATTROPANI, Anna; GONZALEZ, Jerome; DORBAIS, Jerome; KNIGHT, Chris; BAKER-GLENN, Charles; WO2012/4287; (2012); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts