Synthetic Route of 13531-48-1,Some common heterocyclic compound, 13531-48-1, name is Methyl 3-cyanobenzoate, molecular formula is C9H7NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: The reaction was carried out in a 100-mL stainless steel autoclave. Phenylcyanide (0.10 g, 1.00 mmol) was added to a mixture of ethylenediamine (0.12 g, 2.00 mmol), CoCl26H2O (0.24 g, 1.00 mmol) and Zn (0.07 g, 1.00 mmol) and the vessel was placed in an autoclave. For some of the reactions that were carried out in solvent, 5 mL of solvent was also added. The autoclave was pressurized to 5.00 atm with O2. The mixture was stirred in a preheated oil bath at 120 C for 12 h. Then, the reaction mixture was cooled to room temperature and the product was purified by column chromatography on silica gel using n-hexane:CH2Cl2 (1:1) to give the benzamide(88 % yield).
The synthetic route of 13531-48-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Keshipour, Sajjad; Shaabani, Ahmad; Research on Chemical Intermediates; vol. 41; 8; (2015); p. 5071 – 5078;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts