Related Products of 7048-38-6, These common heterocyclic compound, 7048-38-6, name is (5-Chloro-2-methoxyphenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound Z-0-7 (32 g, 177 mmol) was dissolved in methyl formate (400 mL)plusInsodium(8.14 g, 354 mmol).The mixture was protected under nitrogen,Heated to reflux for 24 hThe reaction mixture was cooled to room temperature,Add water to quench the reaction,Ethyl acetate extraction (400 x 2 mL),The combined organic phases were washed with water (200 x 2 mL),Dried over anhydrous sodium sulfate,A yellow solid, Z-0-8 (10.5 g, yield: 28.4percent) was obtained.
The synthetic route of 7048-38-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Haiyan Pharmaceutical Technology Co., Ltd.; Yangzijiang Pharmaceutical Group Co., Ltd.; Lan Jiong; Zhou Fusheng; Huang Dong; Shi Xia; (30 pag.)CN106243003; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts