Some tips on 57381-56-3

The synthetic route of 57381-56-3 has been constantly updated, and we look forward to future research findings.

57381-56-3, name is 2-Chloro-5-fluorobenzonitrile, belongs to nitriles-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C7H3ClFN

Preparation 13: 1-[2-ChIoro-5-(4-methyI-piperazin-1-yl)-phenyl]-ethanone; STEP A; A mixture of 2-chloro-5-fluoro-benzonitrile (1 g, 6.43 mmol), K2CO3 (2.66 g, 19.3 mmol) and 1-methyl-piperazine (1.02 g, 10.26 mmol) in DMSO (14 ml) was stirred at 1000C overnight and then further 1-methyl-piperazine (1.02 g, 10.26 mmol) was added. The mixture was stirred at 1000C overnight and then partitioned between water and Et2O. The organic phase was extracted with 1 M HCI and the aqueous layer was brought to basic conditions with NH4OH and extracted with DCM. The organic phase was dried over Na2SO4 and evaporated in vacuo to give 1 g of 2- chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile. Y= 66%

The synthetic route of 57381-56-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DAC S.R.L.; WO2007/113249; (2007); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts