Reference of 10406-25-4,Some common heterocyclic compound, 10406-25-4, name is 4-(Aminomethyl)benzonitrile, molecular formula is C8H8N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Carborane-1-carboxylic acid (1.0 equiv) and COMU (1.1 equiv) dissolved in DMF, acetone or ethylacetate were reacted with the amine (1.2 equiv) and N,N-diisopropylethylamine (DIPEA, 2.0 equiv) dissolved in DMF, acetone or ethylacetate for 25minat room temperature and purified using the eluent ratio given below. Synthetic details of the optimized procedure in DMF and analytical data of compounds not listed below have recently been reported [33].
The synthetic route of 10406-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Scholz, Matthias S.; Wingen, Lukas M.; Brunst, Steffen; Wittmann, Sandra K.; Cardoso, Ian L.A.; Weizel, Lilia; Proschak, Ewgenij; European Journal of Medicinal Chemistry; vol. 185; (2020);,
Nitrile – Wikipedia,
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