New learning discoveries about 78881-21-7

The synthetic route of 78881-21-7 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 78881-21-7, These common heterocyclic compound, 78881-21-7, name is 4-Amino-3-methylbenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of [6-CHLORO-4-ISOPROPYL-N- (TETRAHYDRO-PYRAN-4-YLMETHYL)-NICOTINAMIDE] (Description 8) (100mg), 4-amino-3-methyl benzonitrile (2eq), cesium carbonate (168mg), tris [(DIBENZYLIDENEACETONE)] palladium (0) (Pd2 (dba) [3)] (3.4mg), 4,5-bis (diphenylphosphino)- 9, 9-dimethylxanthene (Xantphos) (2.3mg) in 1,4-dioxane [(1ML)] was irradiated under microwave conditions at [150C] for 30 minutes. Further quantities of cesium carbonate (168mg), Pd2 (dba) 3 (3.4mg) and Xantphos (2.3mg) were added and the mixture was again subjected to microwave conditions at [150C] for 30 minutes. Ethyl acetate was added and the mixture was washed with water. The ethyl acetate layer was dried (sodium sulphate) and the solvent was removed under reduced pressure. The residue was purified using MDAP to give the title compound (20mg) NMR [(MEOD)] [8] 1.25 (6H, d), 1.29-1. 43 (2H, m), 1.70 (2H, d), 1.81-1. 93 [(1 H,] m), 2.3393H, s), 3.21-3. 50 (5H, m), 3.98 (2H, dd), 7.01 (1 H, s), 7.49 (1 H, dd), 7.55 (1 H, bs), 8.02 (1 H, d), 8.09 [(1H,] s) LC/MS, t = 2.89 min, Molecular ion observed [[MH+]] = 393 consistent with the molecular formula [C23H28N402]

The synthetic route of 78881-21-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/29026; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts