Reference of 107-91-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 107-91-5 name is 2-Cyanoacetamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Pentadione (10 g, 0.1 mol), cyanoacetamide (8.4 g, 0.1 mol) and sodium hydroxide (4 g, 0.1 mol) were added to anhydrous ethanol and stirred overnight at room temperature. The reaction was monitored by TLC and the reaction was stopped. The precipitated solid material was filtered off with suction, washed with a little water, ethanol and diethyl ether and dried to give 4,6-dimethyl-3-cyanopyridone, 142 g, 95.8%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Cyanoacetamide, and friends who are interested can also refer to it.
Reference:
Patent; Sichuan University; Puluo Pharmaceutical Co., Ltd.; Yu Luoting; Wei Yuquan; (24 pag.)CN107573327; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts