Adding a certain compound to certain chemical reactions, such as: 1503-49-7, name is 4-Benzoylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1503-49-7, Quality Control of 4-Benzoylbenzonitrile
To a vial containing 4-benzoylbenzonitrile (0.181 g, 0.873 mmol; prepared according to the procedure described by L.J. omicronomicronbetaepsiloneta and K. Ghosh, Angew. Chem. Int. Ed. 2001, 40, 3458), NBS (0.171 g, 0.961 mmol), p-toluenesulfonic acid monohydrate (0.083 g, 0.437 mmol) and palladium (II) acetate (0.020 g, 0.087 mmol), was added DCE (10 mL). The vial was briefly purged with N2 and then it was sealed and the mixture was stirred at 80C (block temperature) overnight. The cooled mixture was evaporated and the residue was taken up in a minimum volume of DCM and then adsorbed on a silica gel pre-column. Flash chromatography (ISCO/ 0-50% EtOAc-hexane) gave 4-benzoyl-2- bromobenzonitrile (0.138 g, 55.2% yield) as a white crystalline solid. LC-MS (Method J): 1.272 min, [M + H]+ = no ion observed; H NMR (400 MHz, OMSO-d6) delta ppm 8.11 (d, J= 7.8 Hz, 1H), 8.09 (d, J= 1.2 Hz, 1H), 7.81 (dd, J= 1.6, 7.8 Hz, 1H), 7.76 (d, J= 7.4 Hz, 2H), 7.72 (t, /= 7.4 Hz, 1H), 7.58 (t, /= 7.6 Hz, 2H).
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Reference:
Patent; UNIVERSITE DE MONTREAL; BRISTOL-MYERS SQUIBB COMPANY; PRIESTLEY, Eldon, Scott; REZNIK, Samuel, Kaye; RUEDIGER, Edward, H.; GILLARD, James, R.; HALPERN, Oz, Scott; JIANG, Wen; RICHTER, Jeremy; RUEL, Rejean; TRIPATHY, Sasmita; YANG, Wu; ZHANG, Xiaojun; (642 pag.)WO2018/5591; (2018); A1;,
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