In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 53312-79-1 as follows. Computed Properties of C7H5ClN2
A solution of 3-amino-4-chlorobenzonitrile (562mg, 3.69mmol) and sodium phenyl sulfide (731mg, 5.53mmol) of a DMF solution (3.7 ml) was stirred using a microwave reaction apparatus at 150 C 50 min. The reaction mixture was added a saturated aqueous ammonium chloride solution, extracted with ethyl acetate, and the organic layer was washed with saturated brine and water, dried over anhydrous magnesium sulfate. After the drying agent was filtered off and concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (ethyl acetate / hexane) to give (637mg, 76%) of the title compound as a colorless solid
According to the analysis of related databases, 53312-79-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHUGAI SEIYAKU KABUSHIKI KAISHA; MURATA, TAKESHI; HARA, SOUSUKE; NIIZUMA, SATOSHI; HADA, KIHITO; KAWADA, HATSUO; SAKAITANI, MASAHIRO; SHIMADA, HIDEAKI; NAKANISHI, YOSHITO; (453 pag.)TW2016/5805; (2016); A;,
Nitrile – Wikipedia,
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