Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 144649-99-0, name is 5-Bromo-2-methoxybenzonitrile, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C8H6BrNO
16.23 ml of n-butyllithium solution (1.6M in hexane) are added dropwise to a solution of 5.00 g of 5-bromo-2-methoxybenzonitrile in 90 ml of dry tetrahydrofuran at -78C. After stirring at this temperature for 45 minutes, 6.71 ml of triisopropylborate are added, and the mixture is then slowly warmed to -20C. 50 ml of 1 N HCl are added to the reaction mixture. The phase is separated and the aqueous phase is extracted three more times with 100 ml of diethyl ether each time. The combined organic phases are dried with sodium sulphate, filtered and evaporated. The remaining oil is mixed with pentane, and the precipitate which separates out is filtered off with suction and washed once with a little dichloromethane. Drying under high vacuum affords the title compound as a white solid. Rt = 2.74.
According to the analysis of related databases, 144649-99-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Speedel Experimenta AG; EP1987834; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts