Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 499983-13-0, name is 4-Bromo-3-fluorophenylacetonitrile, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 499983-13-0
Step 6: Preparation of 1 -(4-bromo-3-fluorophenyl)cyclopropanecarbonitrile; To a room temperature solution of (4-bromo-3-fluorophenyl)acetonitrile from Step 5 (6.4 g) in a solution of 7.5 mL of sodium hydroxide (50% in water WAV) were added l-bromo-2-chloroethane (4.0 mL) and benzyltriethylammonium chloride (204 mg). The mixture was heated at 600C for 5 hours. The reaction mixture was cooled to room temperature and poured into water (100 mL). The aqueous phase was extracted with ethyl acetate (200 mL). The combined organic extracts were washed with water (100 mL), hydrogen chloride (100 mL, 10% HCl in water) and brine and then dried with magnesium sulfate and the solvent removed in vacuo. The residue was purified by swish using methyl t- butyl ether and hexanes to yield the title compound.1H NMR (CD3COCD3) delta 7.69-7.73 (1 H, m), 7.28 (1 H, d), 7.25 (1 H, d), 1.80-1.87 (2 H, m), 1.59-1.65 (2H, m).
According to the analysis of related databases, 499983-13-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2006/133559; (2006); A1;,
Nitrile – Wikipedia,
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