Related Products of 4426-11-3,Some common heterocyclic compound, 4426-11-3, name is Cyclobutanecarbonitrile, molecular formula is C5H7N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of cyclobutanecarbonitrile (0.70 g, 8.6 mmol) and 2-chloro-6-fluorobenzoic acid (0.5 g, 2.9 mmol) in THF (9.6 mL) at 0 C.Was added KHMDS (0.5 M in toluene, 12.6 mL, 6.3 mmol). The resulting mixture was heated at 70 C. for 3 h, then cooled and concentrated in vacuo. The residue was taken up in 20 mL H 2 O and extracted three times with Et 2 O. The aqueous layer was acidified with 2 N HCl and extracted with CHCl 3 / i-PrOH (3: 1). The combined organic portion was dried over Na 2 SO 4 and concentrated. This crude residue was used directly.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Cyclobutanecarbonitrile, its application will become more common.
Reference:
Patent; Mrck Sharp and Dohme Corp; Blair T, Lapointe; Peter H, Fuller; Hakan, Gunaydin; Kun, Liu; Daneille F, Molinari; Qinglin, Pu; Mark E, Scott; B Wesely, Trotter; Hongjun, Zhang; (117 pag.)JP2018/531957; (2018); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts