Synthetic Route of 89642-49-9, A common heterocyclic compound, 89642-49-9, name is 4-Bromo-3-nitrobenzonitrile, molecular formula is C7H3BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3.48. Compound 49: (lR,2R)-N-(6-(5-cyano-2-ethylphenylamino)-l-methyl-lH-imidazo[4,5- 3.48.1. Step i : 3-Nitro-4-vinyl-benzonitrile A mixture of 4-bromo-3-nitro-benzonitrile (1.0 eq, 1.0 g), potassium vinyl trifluoroborate (1.5 eq, 0.89 g), PdCl2(dppf).DCM (0.05 eq, 201 mg), K2C03 (3.0 eq, 1.82 g) in THF/water (10: 1; 20 mL) is heated at 80 C. After 1 h, the resulting mixture is diluted with DCM and aq. sat. NaHCOs, passed through a phase separator and concentrated. The residue is used as such in the next step.
The synthetic route of 89642-49-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; MAMMOLITI, Oscar; QUINTON, Evelyne; JOANNESSE, Caroline, Martine, Andree-Marie; DE BLIECK, Ann; BLANC, Javier; (263 pag.)WO2017/12647; (2017); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts