Synthetic Route of 123-06-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 123-06-8 name is Ethoxymethylenemalononitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: Hydrazine monohydrate (26.7 mul, 0.55 mmol) was added to a solution of (ethoxymethylene)malonic acid derivatives 4a-d (0.50 mmol) in EtOH (0.5 ml), and the solution was subjected to microwave irradiation (4a: 80C, 4b: 150C, 4c,d: 120C; 150W; 10 min). Afterwards, water (0.5 ml), aldehydes 2a-j (0.55 mmol), TFA (7.7 mul, 0.10 mmol) and isocyanides 3a-d (0.55 mmol) were sequentially added to the solution, and the reaction was stirred for 10-60 min at room temperature. The precipitated product was filtered, washed with hexane or diethyl ether (1-3 ml) and dried in vacuo, yielding the corresponding final products 6-41 and 46-51. In case of 42-45, the crude reaction mixtures were purified by flash chromatography with hexane-EtOAc as eluent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethoxymethylenemalononitrile, and friends who are interested can also refer to it.
Reference:
Article; Demjn, Andrs; Gyuris, Mri; Woelfling, Jnos; Pusks, Lszl G.; Kanizsai, Ivn; Beilstein Journal of Organic Chemistry; vol. 10; (2014); p. 2338 – 2344;,
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