Related Products of 215800-25-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 215800-25-2, name is 2-(4-Bromo-3-methylphenyl)acetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
4-bromo-3-methylphenylacetonitrile (1 g, 4.76 mmol) and methanol (10 mL) were added to a 25 mL singlemouth bottle, and thionyl chloride (5 mL) was added under ice bath. After reacted under ice bath for 20 minutes, the obtained mixture reacted at room temperature overnight. After completion of the reaction, the mixture was concentrated in vacuo to remove the solvent to give the product (colorless oil, 1 g), with a yield of 64.1%. 1H NMR (400 MHz, CDCl3) delta 7.47 (d, J = 8.1 Hz, 1H), 7.15 (s, 1H), 6.96 (dd, J= 8.2, 1.6 Hz, 1H), 3.69 (s, 3H), 3.55 (s, 2H), 2.38 (s, 3H).
The synthetic route of 2-(4-Bromo-3-methylphenyl)acetonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Fudan University; WANG, Yonghui; HUANG, Yafei; YU, Fazhi; TANG, Ting; EP3476829; (2019); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts