Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4110-35-4, name is 3,5-Dinitrobenzonitrile, A new synthetic method of this compound is introduced below., Safety of 3,5-Dinitrobenzonitrile
Example 19 – Preparation of 3-Amino-5-[(7-chloroquinolin-4-yl)amino] benzonitrile hydrochloride (compound 73); Step A: 3,5-Diaminobenzonitrile; To 3,5-dinitrobenzonitrile (5.0 g, 25.89 mmol) in 20 mL of HCI 1 M, was added SnCI2 (34.4 g, 7 eq). The reaction mixture was stirred at room temperature for 2h and then cooled to O’C. The mixture was made alkaline with a 50% aqueous solution of NaOH and the precipitate was removed by filtration. The filtrate was extracted with ethyl acetate and the combined organic layers were evaporated. The residue and the precipitate were purified by flash chromatography on silica gel (DCM/MeOH//95/5) to yield expected compound as an orange solid (1 .95 g, 57% yield), m/z (ESI) 134.0 [M+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE LILLE 2 DROIT ET SANTE; DELACOURTE, Andre; MELNYK, Patricia; BURLET, Stephane; LEFUR, Nicolas; WO2011/73322; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts