Application of 2469-99-0, These common heterocyclic compound, 2469-99-0, name is 3-Oxobutanenitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: First of all, a mixture of 3-oxoalkanonitrile (1 mmol) and hydrazine hydrate (55% aq) (2 mmol) was magnetically stirred in ethanol (5 ml) for 2h under room temperature condition. After completion of the reactions, which was followed by TLC EtOAc:n-hexane 3:1, 2-phthaldehydic acid (1 mmol), CH-acid (1 mmol), and 4-toluenesulfonic acid (0.3mmol) as catalyst were added. Then, the mixture magnetically stirred for 22 h under reflux condition. Reaction solvent was removed by vacuum and participate was washed with methanol. Finally, the residue was purified by recrystallization in mixture of DMSO/methanol (5:2).
The synthetic route of 2469-99-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Alizadeh-Kouzehrash, Meysam; Rahmati, Abbas; Tetrahedron; vol. 76; 7; (2020);,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts