Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1223434-15-8, name is Methyl 4-bromo-2-cyanobenzoate, A new synthetic method of this compound is introduced below., name: Methyl 4-bromo-2-cyanobenzoate
Into a 100-mE 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed methyl 4-bromo-2-cyanobenzoate (2.0 g, 8.33 mmol, 1.00 equiv), ether (40 mE), 2-(propan-2-yloxy)propane propan-2-ol propan-2-yltitanium dihydrate (2.75 mE, 1.10 equiv). This was followed by the addition of EtMgl3r (3M) (5.5 mE, 2.00 equiv) dropwise with stirring at 0 C. The resulting solution was stirred for 3 hour at room temperature. The reaction was then quenched by the addition of 20 mE of hydrogen chloride (1M). The resulting solution was extracted with ethyl acetate (50 mEx2) and the organic layers combined and dried over anhydrous sodium sulfate. The residue was applied onto a silica gel colunm with ethyl acetate/petroleum ether (7/3). This resulted in 409mg (2 1%) of 6?-bromospiro[cyclopropane- 1,1 ?-isoindolin] -3-one as a yellow solid. EC-MS (ESj: mlz 238.00, 240.00 [MH], tR=0.79 mm, (1.90 minute run).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Arvinas, Inc.; Crew, Andrew P.; Berlin, Michael; Dong, Hanqing; Homberger, Keith R.; Qian, Yimin; Snyder, Lawrence B.; Wang, Jing; Zimmermann, Kurt; (504 pag.)US2018/215731; (2018); A1;,
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