Related Products of 38469-83-9, The chemical industry reduces the impact on the environment during synthesis 38469-83-9, name is 4-Methoxy-2-nitrobenzonitrile, I believe this compound will play a more active role in future production and life.
EXAMPLE 2 2-Amino-4-methoxybenzamide To a solution of 37.4 g (0.210 mol) of 4-cyano-3-nitroanisole in 500 mL of ethanol was added 221.6 g (0.982 mol) of tin(II) chloride dihydrate. The reaction mixture was stirred and heated under reflux for 1 hour. After cooling to room temperature, the reaction mixture was poured onto ice. Aqueous sodium bicarbonate was added slowly to the ice mixture until the solution reached pH 7-8. Additional water was added to the mixture, which was then extracted with methylene chloride (2*400 mL) and ethyl acetate (1*300 mL). The separated aqueous layers were filtered between each of the extractions. The off white residue collected on the filters was rinsed with methylene chloride and ethyl acetate several times. The combined organic phases were then dried over magnesium sulfate, filtered and evaporated in the rotary evaporator to obtain 28.5 g crude product (mp 154-155 C.). Elemental analysis for C8 H10 N2 O2: Calc’d: C, 57.82; H, 6.07; N, 16.86; Found: C, 57.95; H, 5.95; N, 16.78.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Methoxy-2-nitrobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; American Home Products Corporation; US5948775; (1999); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts