In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14447-18-8 as follows. COA of Formula: C10H9NO2
In a 500 mL three-neck flask reactor equipped with a thermometer,Benzyl cyanoacetate 63 mL (0.5 mol) was added,Pyridine 10mL,N-octadecyl-3-aminoacrolein42mL (0.25mol),Place the prepared device in the microwave.Set microwave radiation conditions, 35C temperature,The microwave power is 20W and the frequency is 2450MHz.TLC test (petroleum ether:dichloromethane 1:2 development, sublimation iodine coloration) N-octadecyl-3-aminoacrolein reaction was complete, cooled to room temperature, HCl gas was introduced, and the reaction was continued under microwave irradiation ,HPLC followed the reaction until the reaction was over. Add concentrated ammonia to adjust the pH = 5-6, liquid,The aqueous layer was extracted with 1,2-dichloroethane (20 mL¡Á3 times), and the organic layers were combined and washed with water.The solvent 1,2-dichloroethane was distilled off under reduced pressure to obtain 2-chloronicotinic acid benzyl ester.The yellowish liquid was 59.1 g, and the yield was 95.4%.
According to the analysis of related databases, 14447-18-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong Normal University; Liu Yufa; Li Dechao; Gu Qiaolian; Sun Lin; Xu Jun; Zhao Jianxia; Cheng Guiying; (11 pag.)CN104945316; (2018); B;,
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