Adding a certain compound to certain chemical reactions, such as: 3672-47-7, name is 3-(4-Methoxyphenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3672-47-7, SDS of cas: 3672-47-7
3-(4-methoxyphenyl)-3-oxopropanenitrile (2) (2.8571 mmol, 1 equiv.) and hydroxylamine hydrochloride (H2NOH.HCI) (2.8856 mmol, 1.05 equiv.) were added to solution of sodium hydroxide (NaOH) (5.8570 mmol, 2.05 equiv.) in water. The reaction mixture was refluxed for 4 h. After the resulting mixture cooled down to RT, it was diluted with water and extracted with dichloromethane (DCM). The organic layer was dried, filtered and evaporated to give the crude product, which was purified by automated -flash chromatography on silica gel (24 g) eluting with a gradient of 0-60% ethyl acetate (EtOAc) in hexane. Yield 59%. MP: 135.4-137.2C. HRMS (m/z): [M+H]+ calculated for C H N O : 191.0821; found: 191.0812
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(4-Methoxyphenyl)-3-oxopropanenitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BANO?LU, Erden; CALI?KAN, Burcu; ?AH?N, Oezguer; LENGERL?, Deniz; AKBULUT, Oezge; (39 pag.)WO2020/18039; (2020); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts