Electric Literature of 19924-43-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19924-43-7 as follows.
GP 8b was applied in the synthesis of the following nitriles; General Procedure 8b (GP 8b): Cyclopropanation conditions B; To a stirred mixture of the respective benzyl cyanide (1.0 eq.), triethylbenzylammonium chloride (2 to 4 mol%) and 1 -bromo-2-chloroethane (2 to 5 eq.) was added dropwise 50% aq. NaOH solution (6-8 eq.). After complete addition the reaction is stirred at 40-50 0C until complete turnover. The reaction mixture was then diluted with water, the organic products extracted with benzene, the combined organic extracts were washed with 5% aq. HCl and subsequently with water, dried and concentrated in vacuo. The crude products were in general used for the subsequent nitrile hydrolysis without further purification.
According to the analysis of related databases, 19924-43-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BAYER SCHERING PHARMA AKTIENGESELLSCHAFT; WO2007/144203; (2007); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts