Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67832-11-5, name is 4-Bromo-2-methylbenzonitrile, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-2-methylbenzonitrile
[ TERT-BUTYL 4- (4-CYANO-3-METHYLPHENYL)-3, 6-DIHYDROPYRIDINE-1 (2H)-CARBOXYLATE] [4-BROMO-2-METHYL-BENZONITRILE] (150 mg, 0.77 mmol), tert-butyl [4- (4,] 4, [5,] 5-tetramethyl- 1, 3, 2-dioxaborolan-2-yl)-3, [6-DIHYDROPYRIDINE-1] [(2H)-CARBOXYLATE] (284 mg, 0.92 mmol) and [PDCL2] (dppf) (38 mg, [0.] 05 mmol) were dissolved in toluene (2. [5] ml), [ETOH] (0.75 ml) and 2M aqueous [NA2CO3.] The reaction vessel was purged with nitrogen and heated at [80 C] over night. After cooling, the mixture was partitioned between EtOAc and H2O. The organic layer was washed with brine, dried over [NA2SO4] and purified using flash chromatography (heptane: [ETHYLACETATE] 7: 1) affording 171 mg (74%) of white crystals. [LC-MS M/Z 199 [M+].] IH NMR [(CDCI3)] : [8] 7.52 [(1H,] d, J=8. 09 Hz); 7.27 [(1H,] s); 7.23 [(1H,] d, [J=8.] 51 Hz); 6.12 [(1H,] bs); 4.07 (2H, q, J=5. 81 Hz); 3.61 (2H, t, J=5. 61 Hz); 2.52 (3H, s); 2.48 (2H, bs); 1.47 (9H, s).
The synthetic route of 67832-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2004/24718; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts