Application of 77-57-6, These common heterocyclic compound, 77-57-6, name is 1-Phenylcyclopentanecarbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-phenylcyclopentane-1-carbonitrile (1.530 g, 8.935 mmol) prepared in step 1 and polyphosphoric acid (115.00%, 5mL) mixed at room temperature after stirring at 110 C for 17 hours, the reaction was terminated by lowering the temperature to room temperature. The mixture was slowly added to a saturated aqueous solution of sodium bicarbonate (300 mL) at 0 C and then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and water was removed with anhydrous magnesium sulfate, followed by filtration and concentration under reduced pressure. Ethyl acetate (10 mL) was added to the concentrate, and the precipitated solid was stirred and washed with ethyl acetate and dried to give the title compound (1.340 g, 79.2%) as a white solid.
The synthetic route of 77-57-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chong Kun Dang Co., Ltd.; Kim, Yoon Tae; Lee, Chang Sik; Oh, Jung Taek; Song, Hey Sung; Choe, Jin; Lee, Jae Young; (210 pag.)KR2017/43091; (2017); A;,
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