Adding a certain compound to certain chemical reactions, such as: 21667-62-9, name is 3-(3-Chlorophenyl)-3-oxopropanenitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21667-62-9, category: nitriles-buliding-blocks
To 3-chlorobenzoylacetonitrile (24,360 mg, 2 mmol) and sulfur (76 mg) in [DUT] [(4] mL), triethylamine (0. [25ML)] is added under stirring. To this solution [TETRAHYDROTHIOPYRAN-4-ONE] (11,232 mg, 2 mmol) is added dropwise. The mixture is stirred for 16 hours and it is poured into water (30 [ML),] which is extracted with diethyl ether (30 mL). The ethereal solution is dried with sodium sulfate and concentrated to give the desired compound as an orange solid (373 mg, [78%).] Physical characteristics: MS [(ES+)] for [M/Z] 294,296 (M + H).
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Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/35591; (2004); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts