Reference of 633336-81-9, These common heterocyclic compound, 633336-81-9, name is 4-(Aminomethyl)-3,5-difluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 4-aminomethyl-2,6-difluorobenzonitrile (0. [876] g, 5.21 mmol; see step (vi) above) was dissolved in 50 mL of THF and di-tert-butyl dicarbonate (1.14 g, 5.22 mmol) in 10 mL of THF was added. The mixture was stirred for 3.5 h. The THF was evaporated and the residue was partitioned between water and EtOAc. The organic layer was washed three times with 0.5 M HCI and water, dried (Na2SO4) and evaporated. The product could be used without further purification. Yield: 1. 38 g (99%). [‘H] NMR (300 MHz, [CDC13)] 8 7.21 (m, 2H), 4.95 (broad, 1H), 4.43 (broad, 2H), 1.52 (s, 9H)
The synthetic route of 633336-81-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WO2003/101957; (2003); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts