Adding a certain compound to certain chemical reactions, such as: 41963-20-6, name is 4-Bromo-3-methylbenzonitrile, belongs to nitriles-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 41963-20-6, COA of Formula: C8H6BrN
Example 4Reductive Elimination from Pd-F ComplexesGeneral Procedure. In a nitrogen-filled glovebox, a screw-cap NMR tube was charged with (BrettPhos)Pd(Ar)(F) complex, aryl bromide (where applicable) and toluene. The tube was capped and taken out of the box and standard (p-fluorotoluene) was added via syringe. In a Varian 500 spectrometer, a broadband gXH probe was tuned to 19F and heated to 100¡ã C. Over the course of 2-3 h, a 19F-NMR spectrum was obtained every 5 minutes with 5 minutes acquisition time per spectrum. Every spectrum was normalized to the standard to account for differences in the tuning of the NMR probe. Reductive Elimination of 5. See FIG. 14. a) 10 mg (BrettPhos)Pd(2-Me,4-CNC6H3)(F) (13 mummol), 1 mL toluene. The fitted curve shows t1/2=14 min. b) 10 mg (BrettPhos)Pd(2-Me,4-CNC6H3)(F) (13 mummol), 12.5 mg ArBr (64 mummol, 5 eq), 0.6 mL toluene. c) The fitted curve shows t1/2=18 min.
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Reference:
Patent; Massachusetts Institute of Technology; US2011/15401; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts