Reference of 60702-69-4, These common heterocyclic compound, 60702-69-4, name is 2-Chloro-4-fluorobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The mixture of 2-chloro-3-fluorobenznitrile (28) (2.00 g,12.9 mmol), L-leucine (27a, 2.02 g, 15.4 mmol) and cesium carbonate(5.45 g, 16.7 mmol) in DMSO (60 mL) was stirred at 90 C for12 h. The mixture was extracted with aqueous NaHCO3 twice andaqueous phase was combined. The aqueous phase was acidifiedwith citric acid and extracted with EtOAc twice. The organic layerswere combined, washed with brine, dried over MgSO4 and concentratedin vacuo to give 29a (3.43 g, 12.9 mmol, 100%) as a brownoil. 1H NMR (300 MHz, CDCl3) d 0.96 (3H, d, J = 6.0 Hz), 1.01 (3H,d, J = 6.2 Hz), 1.65-1.88 (3H, m), 4.06-4.16 (1H, m), 4.50-4.62(1H, m), 6.50 (1H, dd, J = 8.6, 2.4 Hz), 6.65 (1H, d, J = 2.5 Hz), 7.42(1H, d, J = 8.5 Hz).
Statistics shows that 2-Chloro-4-fluorobenzonitrile is playing an increasingly important role. we look forward to future research findings about 60702-69-4.
Reference:
Article; Aikawa, Katsuji; Asano, Moriteru; Ono, Koji; Habuka, Noriyuki; Yano, Jason; Wilson, Keith; Fujita, Hisashi; Kandori, Hitoshi; Hara, Takahito; Morimoto, Megumi; Santou, Takashi; Yamaoka, Masuo; Nakayama, Masaharu; Hasuoka, Atsushi; Bioorganic and Medicinal Chemistry; vol. 25; 13; (2017); p. 3330 – 3349;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts