Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 101184-73-0, name is 2-(4-Bromophenyl)-2-methylpropanenitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H10BrN
To a stirred solution of 2-(4-bromophenyl)-2-methylpropanenitrile (11.88 g, 53.0 mmol, 1.0 eq.) in THF (150 ml) was added dropwise a solution of B in THF (1.0 N, 159 ml, 159.0 mmol, 3.0 eq.) at an ice-water bath temperature, and the resultant mixture was heated to reflux for 4 hours. The reaction mixture was cooled to ambient temperature, and was concentrated to dryness. The obtained residue was dissolved in methanol, and was heated to reflux for additional (0135) 1 hour. The reaction mixture was concentrated to dryness again, and was treated with water. The aqueous phase was extracted with EA, washed with brine, dried over Na2S04, and was concentrated to dryness. The crude material 2-(4-bromophenyl)-2-methylpropan- 1 -amine was used directly in next step without further purification
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PHARMABLOCK SCIENCES (NANJING), INC.; LIU, Liu; LI, Jin; YANG, Minmin; (126 pag.)WO2019/173804; (2019); A1;,
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