Related Products of 77668-42-9, These common heterocyclic compound, 77668-42-9, name is 2,3-Dichlorobenzoyl cyanide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5. Synthesis of lamotrigine via the tetrafluoroborate saltA solution of aminoguanidinium tetrafluoroborate was freshly prepared from aminoguani- dinium bicarbonate (2.42 g, 17.8 mmol) and anhydrous tetrafluoroboric acid, 53% (v/v) in diethylether (6.18 g), and diluted with acetonitrile (8 mL). 2,3-dichlorobenzoyl cyanide (1.50 g, 7.50 mmol) was added and the reaction mixture was heated to 45 C for 4 hours.In analogy to example 2 the reaction mixture was poured into ice water, yielding the tetrafluoroborate salt of compound II as a suspension which was cooled down to 10 C and filtrated. The filter cake was directly dissolved from the filter at room temperature using essentially pure acetonitrile without any additional solvent. The subsequent cyclization step was performed as described in example 2.
Statistics shows that 2,3-Dichlorobenzoyl cyanide is playing an increasingly important role. we look forward to future research findings about 77668-42-9.
Reference:
Patent; LONZA AG; WO2008/19798; (2008); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts