Related Products of 326-62-5, These common heterocyclic compound, 326-62-5, name is 2-(2-Fluorophenyl)acetonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General Procedure for the Synthesis of Arylquinolines (1). To a solution of 2.38 mmol (1.3 equiv) of an appropriate phenylacetonitrile in 3 mL of anhydrous DMF at 0 C. was added 2.38 mmol (1.3 equiv) of potassium tert-butoxide. The mixture was stirred for 15 min, and 1.83 mmol of 2-aminoaldehyde 5 in 1 mL of anhydrous DMF was added dropwise at 0 C. The mixture was allowed to warm to the room temperature and stirred for 3 h at 90 C. After cooling, the mixture was quenched in water with vigorous stirring. The solution was adjusted to pH 7 only in the case of 2-amino-3-(2-fluorophenyl)quinoline-7-carboxylic acid. A precipitate was collected by filtration and purified by recrystallization and/or chromatography as noted for individual compounds described below.
Statistics shows that 2-(2-Fluorophenyl)acetonitrile is playing an increasingly important role. we look forward to future research findings about 326-62-5.
Reference:
Patent; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION; WATT, David S.; LIU, Chunming; RANGNEKAR, Vivek M.; SVIRIPA, Vitaliy M.; BURIKHANOV, Ravshan; ZHANG, Wen; (22 pag.)US2016/332971; (2016); A1;,
Nitrile – Wikipedia,
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