Synthetic Route of 77-57-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77-57-6, name is 1-Phenylcyclopentanecarbonitrile, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: A 40 ml vial was charged with substrate (0.3 mmol, 1.0 equiv.), Mn(CF3-PDP) 1 (0.03 mmol, 10 mol%), ClCH2CO2H (425 mg, 4.5 mmol, 15.0 equiv.) and a stir bar. Acetonitrile (MeCN, 0.6 ml, 0.50 M) was added along the wall to ensure all compounds were washed beneath the solvent level and the vial was sealed with a screw cap fitted with a polytetrafluoroethylene (PTFE)/silicone septum. The vial was cooled to 0 C with an ice/water bath. A separate solution of H2O2 ((204 mg, 3.0 mmol, 10.0 equiv.), 50% (wt) in H2O, purchased from Sigma-Aldrich) in MeCN (3.75 ml) was loaded into a 10 ml syringe fitted with a 25 G needle and added dropwise to the stirring reaction over 3 h via a syringe pump (1.25 ml h-1 addition rate) while maintaining the reaction vial at 0 C. On completion, the reaction mixture was concentrated to a minimum amount of solvent. The residue was dissolved in ~20 ml dichloromethane (DCM) and washed with 9 ml sat. NaHCO3 solution (caution: CO2 released) to remove ClCH2CO2H. The aqueous layer was extracted with ~15 ml DCM twice and the combined organic layer was dried with Na2SO4. The filtrate was concentrated and purified by flash chromatography on silica gel.
The chemical industry reduces the impact on the environment during synthesis 1-Phenylcyclopentanecarbonitrile. I believe this compound will play a more active role in future production and life.
Reference:
Article; Zhao, Jinpeng; Nanjo, Takeshi; de Lucca, Emilio C.; White, M. Christina; Nature Chemistry; vol. 11; 3; (2019); p. 213 – 221;,
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