Electric Literature of 133116-83-3, The chemical industry reduces the impact on the environment during synthesis 133116-83-3, name is 2-Fluoro-6-(trifluoromethyl)benzonitrile, I believe this compound will play a more active role in future production and life.
Intermediate 30: (2-(piperidin-l-yl)-6-(trifluoromethyl)phenyl)methanamine Step 1: To a solution of 2-fluoro-6-(trifluoromethyl)benzonitrile (CAS: 133116-83-3) (2 mmol) and piperidine (2.2 mmol) in 10 mL of DMF was added K2CO3 (12 mmol). The reaction was stirred at 70 C for 12 h, then cooled to RT. The reaction mixture was then extracted with water and EtOAc, washed with brine, dried over Na2S04, concentrated in vacuo, then purified by prep- TLC to provide 2-(piperidin-l-yl)-6-(trifluoromethyl)benzonitrile as a white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-6-(trifluoromethyl)benzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; KAROS PHARMACEUTICALS, INC.; DE LOMBAERT, Stephane; GOLDBERG, Daniel R.; BRAMELD, Kenneth Albert; SJOGREN, Eric Brian; WO2015/89137; (2015); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts