Related Products of 160892-07-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 160892-07-9 name is 5-Bromoisophthalonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
5-bromoisophthalonitrile (1 g, 48.3 mmol), 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indolo[3,2,1-jk]carbazole (1.77 g, 48.3 mmol) were dissolved in 1,4dioxane (50 ml). K2CO3 (1.34 g, 96.6 mmol) was dissolved in water and poured into the mixture. The reaction mixture was stirred with N2 bubbling for 30 min and refluxed overnight. After cooling to room temperature, the mixture was filtered and diluted with methylene chloride and washed with distilled water. The organic layer was dried over anhydrous MgSO4 and evaporated in vacuum. And then, the product was isolated by column chromatography on a silica gel.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromoisophthalonitrile, and friends who are interested can also refer to it.
Reference:
Patent; RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY; LEE, Junyeob; IM, Yirang; (37 pag.)US2018/114924; (2018); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts