Synthetic Route of 114772-53-1, The chemical industry reduces the impact on the environment during synthesis 114772-53-1, name is 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, I believe this compound will play a more active role in future production and life.
To the glass reactor, 4′-methyl-2-cyanobiphenyl was added5.00 kg, and methanol: 10.00 kgWith stirring2. 07 kg of sodium hydroxide,0.94 kgwaterSolubleliquid,Heated to 80 C, the reaction 10 hours,TLC test (developing solvent = petroleum ether: ethyl acetate = 1: 1), the reaction finished cooling to 40 C, and stirring 20 to 30 minutes, then add hydrochloric acid pH = 2 or so, stirring 30 minutes after the re-test pH , No change will continue to cool down to room temperature, some solid precipitation, continue stirring for two hours, centrifugal, washed to neutral, the product is dry 10 ~ 12 hours, the product 5. 30kg, yield 91. 06%Melting point 146 ~ 148 C, purity 99. 12%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4′-Methyl-[1,1′-biphenyl]-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; weite hunan pharmaceutical co ltd; He, liang; Luo, hui; Mo, wei; (10 pag.)CN105399627; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts