Application of 4435-14-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4435-14-7, name is 2-Cyclohexylacetonitrile belongs to nitriles-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 0.846 g (8.1 mmol) of hydroxylamine hydrochloride in 1 1 mL of isopropyl alcohol, 1 .499 g (17.8 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25 C to 30 C for 10 – 15 min. 1 .0 g (8.1 mmol) of 2- cyclohexylacetonitrile was added and stirred at 80 C to 85 C for 3 – 4 h. After completion of the reaction, the reaction mixture was cooled to 25 C to 30 C, filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue. The residue was chased with 5 mL of toluene to yield the title compound.Yield: 0.6 g (47 %).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Cyclohexylacetonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PIRAMAL LIFE SCIENCES LIMITED; SIVAKUMAR, Meenakshi; JOSHI, Kalpana Sanjay; AWARE, Valmik Sopan; SARDE, Ankush Gangaram; BAGUL, Sandeep Mukunda; MANOHAR, Sonal Mohan; WO2011/104680; (2011); A1;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts