Related Products of 950596-58-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 950596-58-4 name is 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In the reaction flask was charged with 2-amino-4,5-bis (2-methoxyethoxy) – benzonitrile (37.01g, 0.139mol) and acetonitrile (185ml); added 3-ethynyl aniline salt acid (30.00g, 0.195mol), trifluoroacetic acid (17.43g, 0.152mol) and formamidine acetate (15.19g, 0.145mol) in the resultant mixture.The reaction mixture temperature was adjusted to reflux temperature of the solvent, and maintained in this condition for about 15 hours.At the end of the reaction, the temperature was adjusted to about 25 , the solvent was removed by vacuum distillation, and methyl ethyl ketone (430ml).(2 ¡Á 100ml) and water (2 ¡Á 100ml) the organic phase was washed with saturated sodium bicarbonate solution.The organic phase was collected and concentrated by vacuum distillation to a residue.The resulting crude product was suspended in ethyl acetate (450ml), and adding 37% hydrochloric acid solution (14.38g, 0.145mol), maintained at a temperature of 15 for about 30 minutes.The resulting solid was filtered, washed under vacuum at 45 C oven dried to obtain 36.02g erlotinib hydrochloride.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-4,5-bis(2-methoxyethoxy)benzonitrile, and friends who are interested can also refer to it.
Reference:
Patent; Guilin Hui Pak Biotechnology Co., Ltd.; M, Balatella; P, Palanza; M, Garbodi; G, Castaldi; (7 pag.)CN105541735; (2016); A;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts