In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 75279-53-7 as follows. COA of Formula: C8H5ClFN
A solution of 4-chloro-2-fluorobenzeneacetonitrile (0.059 mol) in anhydrous DMF (150 ml) was chilled on an ice-bath. t-BuOK (0.118 mol) was added under nitrogen and the resulting mixture was stirred for 30 minutes. l,2-Dichloro-4-methyl-5- nitrobenzene (0.059 mol) was added and the reaction mixture was stirred for 1 hour at 00C. The mixture was allowed to warm to room temperature for 1 hour and then cooled to 00C. A solution of hydrogen peroxide in water (30%) (17.8 ml) was added and air was bubbled through the solution overnight. The obtained mixture was slowly added dropwise to IN HCl (750 ml) and after stirring in ice-cold DIPE, the resulting precipitate was filtered off, yielding 5.83 g of intermediate (1).
According to the analysis of related databases, 75279-53-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2008/152081; (2008); A2;,
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts